1. Clinical NSAID ulcers are related to the systemic effects of NSAID administration. 2. Most pain medications have some sort of systemic effects like drowsiness. 3. Some chemicals can be absorbed in enough quantity to cause detrimental systemic effects . 4. Other rare systemic effects include decreased blood pressure, fever, rapid heart rate, and convulsions. 5. Drugs administered in this way can have a local effect or a systemic effect . 6. An overdose of dextropropoxyphene may lead to various systemic effects . 7. Yet there remained a lack of carefully controlled studies definitely establishing adverse systemic effects . 8. They may exert their effect locally or produce systemic effects . 9. Adverse effects include muscle spasm and other systemic effects . 10. Enzymes generally act locally to facilitate specific processes, hormones usually have a global, systemic effect .
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